Molecular Diagnostics

01 Pathogen Diagnostics

biocores molecular pathogen diagnostics, predominantly based on single- or multiplex real time PCR, is one of the most comprehensive services on the market and is divided into the diagnostic categories of hepatitis diagnostics and genotyping (HBV, HCV, HDV, HEV), HIV, human papillomavirus (HPV), sexually transmitted diseases, herpes and TORCH infections, respiratory diseases and tuberculosis, neurological infections, gastrointestinal infections and parasites, tick-borne infections, fungi and yeasts, newly diagnosed diseases, bacterial infections / sepsis and resistances. All products have the highest quality standards and are compatible with the most commonly used PCR and real time PCR device platforms in the market. The products are predominantly European standard CE-marked in vitro diagnostics for human medical use.

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02 Oncology

Under the header “Oncology” biocore offers a broad range of tumor-diagnostic tests for early diagnosis and follow-up of patients under therapy. biocore offers as well screening tests as quantitative test which are particularly suited to detect and follow up minimal residual disease (MRD). MRD is the name given to the small number of leukemic or solid tumor cells that remain in the patient during treatment or after treatment, when the patient is in remission (no symptoms or signs of disease). It is the major cause of relapse in cancer and leukemia. Particularly unique are the high-multiplex real-time PCR tests for the simultaneous determination of up to 30 different translocations in acute and chronic leukemias with only one test (HemaVision®, Q-Fusion). In addition to the diagnosis of leukemia, molecular markers of various carcinomas and sarcomas can also be used diagnostically. In addition to the MRD tests, the section also contains a variety of tests for the detection of somatic mutation, which are important for the treatment of various cancers.

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03 Genetic Diseases

In addition to tests for the detection of “classical” genetic diseases such as muscular dystrophy, Fragile- X- syndrome, Chorea Huntington, Cystic fibrosis, etc. the biocore genetic diseases product line includes a large number of tests for the detection of genetic polymorphisms which are responsible for thrombophilia, cardiovascular diseases, diabetes and obesity, as well as tests for detection of genetic resistance to certain drugs (e.g., anticoagulants, warfarin, antibiotics, anti-viral therapy, etc.)

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04 HLA and Blood Group Typing

Transfusion-medical diagnostics with a focus on HLA and blood group typing comprises PCR tests, which are based on conventional PCR / agarose gel electrophoresis, fluorescence endpoint PCR (FluoGene) and real time PCR. FluoGene is an unique modular automated method for molecular HLA, RBC and HPA typing, which combines all the advantages of SSP-PCR with the speed of endpoint fluorescence detection. Sample to result can be achieved in less than 2.5 hrs. The FluoGene tests are supplemented by real time PCR tests for the determination of haplotypes for certain HLA-associated diseases, e.g. Narcolepsy, Behçet’s disease, Celiac disease and Rheumatoid arthritis.

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05 Animal Related Diseases

biocore offers particular molecular tests for the detection of viral and bacterial infections in farm animals (cattle, pigs, sheep, poultry, honeybees), and generally for domestic animals (dogs, cats, horses). In addition, a selection of common mycoses and parasites can also be detected by means of specific tests we offer.

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06 Nucleic acids purification

A variety of manual and automated methods are available for purifying nucleic acids from biological materials for diagnostic purposes. The manual preps provided by biocore comprise kits which contain the complete extraction chemistry to be used in combination with spin filter columns or nucleic acid-binding magnetic beads. The latter are preferred for use in automated protocols and sample volumes of up to 5 mL. The spectrum of available reagents extends to the extraction of genomic DNA or total RNA from cells and tissues to viral and bacterial nucleic acids from blood, plasma, serum or water.

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07 PCR Reagents

For research purposes, we offer various PCR enzymes (Taq polymerases) and enzyme mixes for “one-step RT-PCR”. They are available individually or in the form of master mixes including PCR additives such as dNTPs, cationic cofactors, UDGs and fluorescent dyes. We also offer reagents for classical DNA electrophoresis, such as agarose, molecular weight markers (DNA ladders), buffer concentrates and intercalating DNA dyes.

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08 Food diagnostics

The tests for molecular food diagnostics offered by biocore include the fields of animal specification, the detection of genetically modified organisms (GMO), a variety of food pathogens and food allergens in all types of food and feed using real time PCR.

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